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PRODUCT INFORMATION


Dietary Benefit
Diindolylmethane (DIM) supports the body’s ability to eliminate toxins from the liver [1], optimizes the body’s natural metabolism of hormones, and promotes good estrogen (2-Hydroxyestrone) [2]. This dietary indole antioxidant is an important factor in promoting women’s health.

Dosage
Adults 100 to 200 mg per day.
Children may take up to 1/2 adult dosage.

Product Overview
In cruciferous vegetables such as broccoli, cauliflower, cabbage, and brussels sprouts, a series of compounds react when the vegetable cell walls are broken through chopping, chewing, or juicing [7]. DIM is just one of many Dietary Indoles produced in this way*. DIM is proven to have significant physiological activity [8]

Stability
DIM is stable at room temperature but must be protected from light. The highly-colored degradation products are considered beneficial and are the same as those formed in the stomach upon ingestion.

Alternate Names
Diindolylmethane; 3,3(-Diindolylmethane; Bisindolylmethane; B3IM; BIM




Classification

Dietary Indole CAS Registry Number [1968-05-04]

Regulatory Status
DIM is a Dietary supplement under provisions of US Dietary Supplement Health and Education Act of 1994 (DSHEA).

Warning
Amounts in excess of recommended dosages may cause diarrhea.

References

1. Michnovicz, J. J.; Bradlow, H. L. 1991 Nutr. Cancer 16: 59-66. Michnovicz, J. J.; Bradlow, H. L. 1990 Natl. Can. Inst. 82: 947-949
2. Andrus, G.M., Arffman, K., 1999 United States Patent. 5895787, April 20.
3. Michnovicz J.J., Bradlow H.L., 1993 Food Phytochemicals I: Fruits and Vegetables 282-293.
4. Ge, X., Yannai S., Rennert G., Gruener N., Gares F.A. 1996 Biochem Diophys Res Commun 28:153-165.
5. Bell, M.C., ETL, 2000, Gynecologic Oncology 78: 123-129.
6. Newfield, L., ETL, 1993, Anticancer Research 13: 337-342.
7. Zeligs, M.A., 1998, Journal of Medicinal Food, 1:2, 67-82
8. Loub W.E., Wattenberg L.W., Davis D.W., 1975 J. Nat. Can. Inst. 54: 985-988
9. Michnovicz J.J., Bradlow H.L., 1989 Proc. Royal Soc. Endinburgh 12: 1571-1574

* While these compounds occur naturally, they exist in extremely low quantities. All commercial sources are synthetic.




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