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Dietary Benefit
Ascorbigen helps the body prevent absorption
of toxins through the small and large intestines
[1] and exhibits provitamin [2-6], immunostimu-
latory [3-6], and skin conditioning properties [7]. Ascorbigen’s usefulness is largely attributed to
its ability to support the body’s natural metabolism
of hormones and promote good estrogen (2-Hydroxyestrone) [9].

Adults 200 to 400 mg per day.
Children may take up to 1/2 adult dosage.

Product Overview
Ascorbigen is the most prevalent of several
Dietary Indoles shown to have significant physi-
ological activity [13] and may be the essential
component making Dietary Indoles beneficial [14]. Ascorbigen is a skin-permeable form of Vitamin C
formed from Indole-3-Carbinol in the presence of
aqueous ascorbic acid.

Ascorbigen is produced naturally in cruciferous
vegetable juices when cell walls are broken through chopping, chewing, or juicing* [15]. First identified
in 1935 [16], Ascorbigen was isolated from Savoy
cabbage juice in 1957 [17]. Ascorbigen may exhibit synergy with Indole-3-Carbinol [18-19].

Ascorbigen is the most stable of commercially
available Dietary Indoles. It requires neither refriger-
ation nor protection from light. Degradation will
occur at temperatures in excess of 50ºC. Trace
amounts of more reactive Dietary Indoles contribute
to product color.

Alternate Names
ulofuranosonic acid g-lactone.


Dietary Indole CAS Registry Number [8075-98-7]

Regulatory Status
Ascorbigen is a dietary supplement under provisions of US Dietary Supplement Health and Education Act of 1994 (DSHEA).

Amounts in excess of recommended dosages may cause diarrhea.

1. McDanell, R. et al. 1987 Food and Chemical Toxicology 25: 363-368.
2. Bukin, Y.V. et al. 1987 Khimi IA 13: 539-545.
3. Mukhanov, V.I. et al. 1984 Soviet Journal of Bioorganic Chemistry 10: 544-559.
4. Plikhtyak, I.L. et al. 1988 Khim. Getcrotsikl. Sosdin.131-132
5. Efimox, S.A., 1989 Antibiot. Khimioter 34: 125-129.
6. Anonymous, 1978 Analysis and Research (Japan)
16: 546-550.
7. Fukushima, S., Toyoda, H., 1987 Japan Kokai Tokyo Koho Japanese patent. 62/155204 A2 [87/155204] July 10.
8. Andrus, G.M., Arffman, K., 1999 United States Patent. 5895787, April 20.
9. Michnovicz, J. J.; Bradlow, H. L. 1991 Nutr. Cancer
16: 59-66. Michnovicz, J. J.; Bradlow, H. L. 1990, Natl. Can. Inst. 82: 947-949
10. Sepkovic, D. et al. 1994 Steroids 59: 318-323.
11. Bell, M.C. et al. 2000, Gynecologic Oncology 78: 123-129.
12. Newfield, L. et al. 1993, Anticancer Research 13: 337-342.
13. Loub, W.E., Wattenberg, L.W., Davis, D.W., 1975 J. Nat. Can. Inst. 54: 985-988.
14. Preobrazhenskaya, M. N. andKorolev, A.M. 1992 Journal of the National Cancer Institute 84: 15, 1210-1211
15. Zeligs, M.A., 1998 Journal of Medicinal Food 1:2, 67-82
16. Ahmad, B., 1935 Biochemistry Journal 29: 275
17. Prochazka, Z. et al. Collection of Czechoslovakian 1957 Chemical Communications 22: 333, 654
18. Chinoy, N.J., 1977 Journal of Animal Morphology and Physiology 24: 173-185.
19. Kahatriya, A.M., 1977 Journal of Animal Morphology and Physiology 24: 379-386.

* While this compound occurs naturally, they exist in extremely low quantities. All commercial sources are synthetic.

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Beyond the Shutdown 50: Juron Criner, WR, Oakland RaidersBy Juron Criner is adapt apt act this. (Getty Images)brbrNow that the 2012 NFL draft is among the can, it's period apt take the forward and get a closer discern by some of the amazing and fascinating selections from this year's draft -- the guys we missed amid the aboriginal 50,but who could be impact players now alternatively down the road. Our afterward entry: Arizona receiver?selected?along the with the 33rd pick amid the fifth circuitous (168th overall). brbrOverview: While most of the chat virtually Pac-12 passing attacks among 2011 focused aboard the offenses lecheap baseball jerseysd onward Andrew Luck and Matt Barkley, the Arizona passing? game has been one of the more lush amid the nation within recent seasons -- and recipient may be the primary reason as that. If you're among the crew who believes that former Arizona and fashionable Philadelphia Eagles quarterback Nick Foles pain that aerial attack as many for he helped it with his inaccuracy and questionable decision-making, Criner stands out in sharper relief. After catching seven passes for 88 yards and a touchdown for a true freshman, Criner moved up apt 45/582/9 among 2009, and made a nominate for himself amid 2010,when he caught 82 passes forhockey jerseys cheap an,233 yards and 11 touchdowns. He repeated that touchdown diagram last annual and the recess of the mathematics about matched up (75 for 926).brbrCriner further set himself aboard the radar with an exciting week at the Senior Bowl. :brbrCriner has probably helped his stock more than any additional player during Senior Bowl practices this week ... [He] does not have breakaway velocity,merely he appears apt have the recess of the archive.brbr"I'm quite agile as a man my size," Criner said back Thursday's practice. That agility was obvious earlier among the week,when he made smooth cuts and adjusted apt poorly thrown balls anfl jerseys cheapmid live practices. Criner has also been demonstrating good-looking hands and pass-catching technique, and he looks more fluid and comfortable running routes than some of the additional huge receivers aboard the South squad.brbrJanoris Jenkins (CB, North Alabama), the likely first-round elect who transferred from Florida because of personal issues, singled?Criner out because the hardest South receiver to cover this week during his Thursday click conference. "He's kinda got ball skills," Jenkins said. "If you buffet his hand, he'll catch it. And he's tall."brbrSo, there's that. When he's thrown apt forward good quarterbacks,personalized hockey jerseys Juron Criner tends to tell plays. And even while he's thrown to along quarterbacks who couldn't strike water whether they fell out of a boat, he's going apt do some interesting things. Now a arrogant member of the , Criner has a shot by perform what Tennessee wideout Denarius Moore did amid 2011 -- bring off of nowhere for a late-round pick and impress the NFL,nfl jerseys. Moore went off the fasten amid a relative sense surrounded his neophyte movement catching 33 passes for 618 yards and five touchdowns. Could Criner be the afterward fellow on the Raiders' late-draft boards apt flash that same kind of long-term potential?cheap football jerseybr